March 13 - Battle of Jarnac: Royalist troops under Marshal Gaspard de Tavannes surprise and defeat the Huguenots under the Prince of Condé, who is captured and murdered. A substantial proportion of the Huguenot army manages to escape under Gaspard de Coligny.
June 10 - German Protestant troops reinforce Coligny near Limoges.
August 24 - Battle of Orthez: Huguenot forces under Gabriel de Montgomery defeat Royalist forces under General Terride in French Navarre. Catholics surrender under the condition that their lives will be spared. Huguenots agree, but then massacre the Catholics anyway.
September - A Royalist army under the Duc d'Anjou and Marshal Tavannes forces Coligny to abandon the siege of Poitiers.
October 3 - Battle of Moncountour: The Royalist forces of Tavannaes and Anjou defeat Coligny's Huguenots.
The trade compact of 1536 is renewed, exempting French merchants from Ottoman law and allowing them to travel, buy and sell throughout the sultan's dominions and to pay low customs duties on French imports and exports.