List of years in literature (Table)
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The year 1621 in literature involved some significant events.

Events

• The Corante, generally regarded as "the first English newspaper," is published.
• Sir Francis Bacon is tried and convicted for taking bribes.
• On August 26, Barten Holyday's allegorical play Technogamia, originally produced at Christ Church, Oxford in 1618, is staged before King James at Woodstock Palace. (James didn't like it, but was persuaded to stay to the end for the student actors' sakes.)

New books

• William Alabaster - De bestia Apocalypsis
• Robert Burton - The Anatomy of Melancholy
• Rachel Speght - Mortalities Memorandum
• John Taylor - Taylor's Motto
• John Widdowes - A Description of the World
• Lady Mary Wroth - The Countesse of Mountgomeries Urania

New drama

• Francis Beaumont, John Fletcher, & Philip Massinger - Thierry and Theodoret (published)
• Guillem de Castro - Mocedades del Cid
• Thomas Dekker, John Ford, & William Rowley - The Witch of Edmonton
• Ben Jonson - The Gypsies Metamorphosed
• Tirso de Molina - El vergonzoso en palacio

Poetry

• George Wither - Wither's Motto

Births

• March 31 - Andrew Marvell, poet (d. 1678)
• April 25 - Roger Boyle, 1st Earl of Orrery, dramatist (d. 1679)
• July 8 - Jean de La Fontaine, Fables author (d. 1695)

Deaths

• August 3 - Guillaume du Vair, French writer (b. 1556)
• August 15 - John Barclay, Scottish writer (b. 1582)