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The year 1622 in literature involved some significant events.

Events

• Loiola, a Latin comedy mocking the Jesuits, is acted at Cambridge on February 28, and again before King James I on March 12.
• Lucas Holstenius arrives in Britain to gather material for his Geographi Minores.

New books

• Juan Ruiz de Alarcón - El tejedor de Segovia
• Francis Bacon - The Historie of the Raigne of King Henry the Seventh
• Elizabeth Knyvet Clinton, Countess of Lincoln - The Countess of Lincoln's Nursery
• Marie de Gournay - Egalité des Hommes et des Femmes ("Equality of Men and Women")
• William Shakespeare - Othello (first quarto)

New drama

• Thomas Dekker & Philip Massinger - The Virgin Martyr published
• John Fletcher and Massinger (and Francis Beaumont?) - Beggars' Bush acted at Court
• Fletcher & Massinger - The Spanish Curate
• Ben Jonson - The Masque of Augurs
• Gervase Markham & William Sampson - Herod and Antipater
• Thomas May - The Heir
• Thomas Middleton & William Rowley - The Changeling
• Middleton & John Webster - Anything for a Quiet Life published

Poetry

• John Taylor - The Water Cormorant His Complaint
• George Wither - Faire-Virtue, The Mistresse of Phil Arete

Births

• January 15 - Molière, dramatist (died 1673)
• February 24 - Johannes Clauberg, philosopher and theologian (died 1655)
• April 11 - Jan van Vliet, philologist (died 1666)
• April 17 - Henry Vaughan (died 1695), poet, and Thomas Vaughan (philosopher) (died 1666), philosopher (twins)
• date unknown - Gilbert Mabbot, journalist and licenser of the press 1647-49 (died c1670)

Deaths

• August 21 - Juan de Tassis y Peralta, 2nd Count of Villamediana, poet (murdered) (born 1582)
• date unknown - Henry Ainsworth, clergyman and scholar (born 1571)
• date unknown - Sir George Buck, historian (born 1560)
• date unknown - John Owen, writer of epigrams (born 1564)