The title of Earl of Southampton was created three times in the Peerage of England (in 1537, 1544, and 1670). The second creation was associated with a subsidiary title, Baron Wriothesley (created three years earlier). See also Duke of Southampton, Baron Southampton.

Earls of Southampton, 1st Creation (1537)

• William Fitzwilliam, 1st Earl of Southampton (1490-1542)

Earls of Southampton, 2nd Creation (1544)

• Thomas Wriothesley, 1st Earl of Southampton (1505-1550)
• Henry Wriothesley, 2nd Earl of Southampton (1545-1581)
• Henry Wriothesley, 3rd Earl of Southampton (1573-1624)
• Thomas Wriothesley, 4th Earl of Southampton (1607-1667)

Earls of Southampton, 3rd Creation (1670)

• see Duke of Cleveland, first creation