Francis I may refer to:

• Francis I, Duke of Brittany (1414-1450, reigned 1442-1450)
• Francis I, Duke of Lorraine (1517–1545, reigned 1544–1545)
• Francis I of France (1494-1547, reigned 1515-1547)
• Francesco I de' Medici, Grand Duke of Tuscany (1541-1587, reigned 1574-1587)
• Francesco I d'Este, Duke of Modena (1644-1658)
• Francis I, Holy Roman Emperor (1708-1765, reigned 1745-1765)
• Francis II, Holy Roman Emperor, also Francis I, Emperor of Austria, (1768-1835, reigned 1804-1835)
• Francis I of the Two Sicilies (1777-1830, reigned 1825-1830)

This disambiguation page lists articles associated with the same personal name. If an article link led you here, you may wish to change the link to point directly to the intended article.