Guido delle Colonne (in Latin Guido de Columnis or de Columna) was an early 13th century Sicilian writer, living at Messina, who wrote in Latin. He is the author of a prose narrative of the Trojan War entitled Historia destructionis Troiae ("History of the destruction of Troy").

Dante (De vulgari eloquentia 2.5) named Guido as a poet in the vernacular, and in fact five poems by him in Italian survive.