M27 or M-27 may refer to:

• Messier 27 (M27), a planetary nebula also called the Dumbbell Nebula
• M27 motorway, a motorway in England
• M27 motorway (Russia)
• M27 Mosin-Nagant, a Finnish rifle
• M-27 (Michigan highway), a state highway in Michigan
• Manitoba Highway 27, a provincial highway in Manitoba

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