The Oregon Trail was a historic migration route across the western United States.

Oregon Trail may also refer to:

• The Oregon Trail (computer game), a computer game
• The Oregon Trail: Sketches of Prairie and Rocky-Mountain Life, a book by Francis Parkman
• Oregon Trail (1945 film)
• The Oregon Trail (1923 serial), a 1923 film serial
• The Oregon Trail (1936 film), starring John Wayne
• The Oregon Trail (1939 serial), a 1939 serial
• The Oregon Trail (1959 film)
• The Oregon Trail (TV movie), a 1976 television movie
• The Oregon Trail (TV series), a 1977 television series
• Oregon Trail Junior High, a school in Kansas

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