Thomas Gates may refer to:
- Sir Thomas Gates (governor) (1585–1621), of the Virginia Company, an early leader and governor of the Colony of Virginia
- Thomas Sovereign Gates (1873–1948), U.S. educator, first president of the University of Pennsylvania
- Thomas Sovereign Gates, Jr. (1906–1983), U.S. Secretary of Defense under President Dwight D. Eisenhower
- Thomas Gates, 19th-century Tuscon, Arizona area pioneer, rancher, and saloonkeeper; Gates Pass is named after him
- USS Thomas S. Gates (CG-51)
- Thomas Gates, fictional character in National Treasure: Book of Secrets, portrayed by Joel Gretsch
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