William Hughes may refer to:
- Billy Hughes (1862–1952), seventh prime minister of Australia
- William Hughes (writer) (1803–1861), writer on law and angling
- William Hughes (Senator) (1872–1918), U.S. senator from New Jersey
- William Hughes, Baron Hughes (1911–1999), Scottish Labour party politician
- William J. Hughes (born 1932), former member of the U.S. House of Representatives from New Jersey and Ambassador
- William Hughes (geographer) (19th century), professor of the geography of the Holy Land (Middle East) to divinity students at King's College London, circa 1863
- William Hughes (Mr. W. H.) (16th century), possible dedicee of Shakespeare's Sonnets
- Bill Hughes (police), Director General of Britain's Serious Organised Crime Agency
- Skinny DeVille (real name William Hughes), member of hip-hop/rap group Nappy Roots
- William Hughes (professor), professor of gothic studies, and author/editor of several books on Bram Stoker and the Gothic
- William Alfred Carroll Hughes, bishop
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